Liquid chromatography‐electro spray ionization tandem mass spectrometry for simultaneous determination of Moexipril and its active metabolite Moexiprilat in human plasma
نویسندگان
چکیده
a Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo, 11566, Egypt b Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Helwan University, Cairo, 11431, Egypt c Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Ahram Canadian University, 6th of October, 12566, Egypt d Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, 12316, Egypt
منابع مشابه
High-performance liquid chromatography combined with a UV absorbance detector and electrospray ionization mass spectrometer is used for the simultaneous analysis of moexipril and moexiprilat in biological samples. Moexipril and moexiprilat
Moexipril hydrochloride [(3S)-2-[(2S)-2-{[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino}-1-oxopropyl]-6,7-dimethoxy1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride] (Figure 1A) is a long-acting, non-sulfhydryl angiotensin-converting enzyme inhibitor (ACEI) used in the treatment of hypertension (1). Moexipril can be preferentially used to lower blood pressure without a significant c...
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